Abstract
Chewable gel tablets are an underdeveloped subject, even though there are many simple chewable tablets and gummy candies in the food and pharmaceutical industries. Chewable gel tablets are not as sweet, they can have an active substance, pharmacological effect, and a value of nutrition. The aim of this study was to prepare gelatin-based chewable tablets with Myristica fragrans as a preservative and to determine the shelf-life variability depending on storage conditions, and to evaluate texture changes. Firmness and springiness of gel tablets were measured by a texture analyzer and compared between different storage conditions and the shelf-life of tablets was established by mold growing time. Chewable gel tablets were prepared by using silicone form. Mold was most likely to grow on tablets that have been packaged in squeezable bags (after 14 days 60% of all formulations had a mold, p < 0.05). The most stable tablets (over 180 days) were in sealed boxes and contained nutmeg essential oil or its solution, or ethanolic nutmeg extract. The gel tablets’ firmness increased about 4 times when they were stored in opened plastic boxes and their springiness decreased about 1.65 times after 28 days in the mentioned conditions, p < 0.05. Nutmeg hydrolat had the highest influence on texture variation (p < 0.05).
Highlights
Chewable tablets are a popular dosage form for children, elderly patients or for those who have swallowing disorders
Concentrations of gelatin can vary greatly depending on which gelatin is selected, there are many categories of gelatin which can be used in food or pharmaceutical industry [10]
Chewable gel tablets are similar to gummies or candies, but they differ from them—they are eaten not as a desert but as a food supplement or a medical substance, and they have a medical and nutrition purpose because they are equivalent to chewable tablets which have a recognition in the European Pharmacopoeia [6]
Summary
Chewable tablets are a popular dosage form for children, elderly patients or for those who have swallowing disorders. The most popular chewable tablets are tablets such as paracetamol, acetylsalicylic acid, ibuprofen [3] or other tablets which have an active substance and many excipients, and are mostly opaque or white in color, and are prepared by compression Another group of chewable tablets are chewable gel tablets which are commonly referred to as gummies [4,5]. Chewable tablets have a pleasant taste and leave no bitterness or an unpleasant taste after eaten They have many advantages compared to another pharmaceutical forms: they are easy to administrate, water is unnecessary, teaspoons or other cutlery are not required; therapeutic effect of an active substance can be terminated by discarding it before complete ingestion, and they can be used for systemic drug delivery [2,7]
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