Abstract
BackgroundPoor ovarian response to gonadotropin is a significant challenge in assisted reproductive technique (ART) and affect 9–24% of ART cycles. This study aimed to evaluate the effect of Myo-inositol on fertility rates in poor ovarian responder women undergoing assisted reproductive technique.MethodsThis study is a double-blinded randomized controlled study that involved 60 poor ovarian responders included in an ICSI program and divided into two groups; intervention group: 30 patients who have been assuming Inofolic (4 g myo-inositol + 400 μg folic acid) for the before the enrollment day; control group: 30 patients assuming folic acid (400 μg) for the same period. Controlled ovarian stimulation was performed in the same manner in the two groups. The main outcomeswere the assessment of oocytes retrievednumber and quality, ovarian sensitivity index,required dose of Gonadotropinsunits × 1000), fertilization rate, biochemical, and clinical pregnancy rate.ResultThere is no significant difference in clinical characteristics between study groups. The number of oocytes retrieved, number of MII oocytes, number of embryos transferred, chemical, and clinical pregnancy were higher in the intervention group. However, they are not statistically significant in comparison to the control group. The ovarian sensitivity index and fertilization rate were significantly higher in the intervention group than the control group (P > 0.05). The required dose of gonadotropin significantly lower in the intervention group than the control group.ConclusionOur results suggest that the supplementation myo-inositol in poor ovarian responders significantly improved the ART outcomes such as fertilization rate gonadotropin, ovarian sensitivity index (OSI) and significantly reduced the required unities of gonadotropin. Additionally, more extensive randomized controlled studies are needed.Trial registrationIranian Registry of Clinical Trials, IRCT20180515039668N1, retrospectively registered since 2020-03-16.
Highlights
Poor ovarian response to gonadotropin is a significant challenge in assisted reproductive technique (ART) and affect 9–24% of ART cycles
The poor ovarian response is the most important limiting factors in the success of in-vitro fertilization (IVF), which is observed in 9–24% of women which are undergoing assisted reproduction techniques [1, 2]
Recent studies have shown that high concentrations of myo-inositol in follicular fluid have a significant role in follicle maturation and markers of good quality ovulation [8]
Summary
Poor ovarian response to gonadotropin is a significant challenge in assisted reproductive technique (ART) and affect 9–24% of ART cycles. This study aimed to evaluate the effect of Myo-inositol on fertility rates in poor ovarian responder women undergoing assisted reproductive technique. The poor ovarian response is the most important limiting factors in the success of in-vitro fertilization (IVF), which is observed in 9–24% of women which are undergoing assisted reproduction techniques [1, 2]. Some biochemical characteristics of follicular fluid surrounding oocyte may play a decisive role in determining the quality of the egg, and they arepotential factors for achieving fertilization and fetal development [6, 7]. Recent studies have shown that high concentrations of myo-inositol in follicular fluid have a significant role in follicle maturation and markers of good quality ovulation [8]
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