Abstract
17beta‐hydroxysteroid dehydrogenase type 10, also known as 3‐hydroxyacyl CoA dehydrogenase type 2, is variously abbreviated as HSD10, ABAD, ERAB, SDR5C1 or HADH2. The gene for this homotetrameric mitochondrial enzyme, designated as HSD17B10, is found on the X chromosome. Mutations in this protein are associated with neurodegenerative disorders.In addition to its enzymatic activities, HSD10 is a structural component of human ribonuclease P (7ONU.pdb) and is bound to beta‐amyloid during Alzheimer's disease (1SO8.pdb).This study examines single nucleotide polymorphisms found in HSD17B10 for their possible effects on protein structure, protein‐protein interactions, and protein‐ligand interactions, concentrating on the NAD+ binding site. This study compares the mutations that result from these polymorphisms to the sequence differences between rat and human HSD10.
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