The Effect of Multi-vector Drugs on the Activity of Glutathione Peroxidase in the Blood and Tissues of the Kidneys of Rats in the Simulation of Acute Pyelonephritis and Concomitant Type 1 Diabetes

Abstract

The objective: to determine the activity of the enzyme antioxidant system glutathione peroxidase in blood plasma and kidney tissues of rats in the simulation of acute pyelonephritis (OD) and concomitant streptozotocin diabetes mellitus (DM) type 1.Materials and methods. Experimental studies were performed on Wistar rats weighing 200–300 g at the age of 8–9 months. Animals were divided into five groups.Results. In acute pyelonephritis, the activity of glutathione peroxidase in blood plasma and in kidney tissues of animals was significantly reduced, and when simulated in acute pyelonephritis rats against the background of type I diabetes, the activity of glutathione peroxidase in blood plasma decreased almost twice, with respect to uncomplicated SD inflammation. Traditional CF contributed only to the development of a tendency to increase the activity of glutathione peroxidase in blood plasma and in kidney tissue. The enzyme activity remained significantly lower when compared with the norm. With the proposed drug exposure to multivectoral agents, the activity of glutathione peroxidase in plasma and in renal tissue increased significantly in accordance with the group of animals with TMB and improved the enzymatic state of plasma by 48% and by 38% in renal tissue relative to the group of animals without DE.Conclusion. It should be considered pathogenetically significant violations of the detoxification of peroxides and hydroxides in the development of acute pyelonephritis with concomitant type I diabetes mellitus. The use of multi-vector drugs promoted an increase in the activity of glutathione peroxidase in the blood plasma and in the kidneys of animals with acute pyelonephritis complicated by concomitant type I diabetes mellitus.