Abstract
1. The contractile force of trout ventricle strips fell in a dose-dependent manner with increasing concentrations of MS-222. 2. Ventricle strips immersed in a superfusate containing 27 mg l−1 MS-222 had an equivalent concentration in the tissue. At 54 mg l−1 the tissue concentration was significantly lower than the superfusate. 3. A concentration of 10 mg l−1 MS-222 in the perfusate produced a 25% drop in force of contraction of ventricle strips. 4. Isolated perfused hearts pumping perfusate with 10 mg l−1 MS-222 also showed a fall of approximately 25% in maximum cardiac output and maximum power output. 5. Tissue anaesthetic levels in the ventricles of superfused trout hearts were found to be three-fold higher than that in the perfusate. 6. The need for caution when using MS-222 in physiological experiments is therefore emphasized.
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