Abstract
To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.
Highlights
Morphine, a mu opioid receptor agonist, is a frequently used potent analgesic in human and veterinary medicine
Pairwise comparison revealed that morphine administration only altered the regional cerebral blood flow (rCBF) in those regions compared to the baseline condition at T30 (P = 0.047, 0.021 and 0.006 respectively)
Significant left-right differences were found in the forntal cortex for all conditions and in the occipital cortex in the MOR30 condition
Summary
A mu opioid receptor agonist, is a frequently used potent analgesic in human and veterinary medicine. Only few have reported on the hemodynamic effects of morphine on the brain, usually reporting global cerebral blood flow changes with varying results [4,11,12,13,14,15,16]. These discrepancies are probably caused by differences in study design, imaging technique, species, opioid choice, dose and route of administration
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