Abstract
Giving herbal supplements made from moringa leaf extract 70%, fragrant pandanus 20% and red ginger 10% (KPJ) can lower uric acid levels of rat hyperuricemia significantly. To know the industrial scale production process and its influence on the chemical parameters of capsules extract formula KPJ extract conducted analysis of moisture content, total phenols, flavonoids and antioxidant activity (DPPH, FRAP and ABTS). Meanwhile, knowing the effect of herbal supplements formula moringa leaf extract, pandan fragrance, and red ginger to hyperuricemia sufferers, clinical trials conducted phase I on 40 people with hyperuricemia who consume herbal supplements formula moringa leaf extract, pandan leafe, and red ginger for 14 days. Furthermore, checks on uric acid levels, kidney function, and liver function before and after the intervention of herbal supplements formula moringa leaf extract, pandanus, and red ginger to find out the effectiveness of clinical trials phase I. The results showed that the best supplements are produced from the formula of thick extract KPJ as much as 60% and filler ingredients as much as 40%. The supplement has a water content of 5.49%, phenol 10.67mg GAE/g, flavonoids 4.37mg QE/g, DPPH 7.19mg TE/g, FRAP 12.82mg TE/g, ABTS 29.04mg TE/g, IC50 545.57ppm. Phase II research is a clinical trial phase I. This stage aims to determine the influence of KPJ supplements on uric acid levels, kidney function, and liver function before and after intervention and perception of hyperuricemia sufferers after intervention The perception results of hyperuricemia sufferers showed 65% of sufferers experienced a decrease in uric acid levels and 57.5% of sufferers were satisfied with the benefits and results of KPJ herbal supplements in lowering uric acid levels.
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