Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated plasma glucose levels. Gold standard of DM diagnosis is through HbA1c examination. The American Diabetes Association (ADA) and European Association Diabetes Study (EASD) recommend glycated albumin as an alternative biomarker in diagnosing DM. One of the DM therapies can use herbal plants, namely Moringa (Moringa oleifera Lam.). This study aimed to determine the effect of ethanol extract of Moringa leaves (Moringa oleifera Lam.) on glycated albumin levels in wistar strain white rats (Rattus norvegicus) model of diabetes mellitus induced by streptozotocin-nicotinamide. This is an experimental research with post test control group method. Subjects were 36 rats divided into 6 groups. At the end of the study, rats were examined for GA levels using the ELISA method. Data were analyzed using JASP and One-Way Anova test followed by post hoc test. The lowest reduction in glycated albumin levels was found in the group of rats given 300 mg of Moringa leaf ethanol extract (34,397±2,564). One-way anova test showed a significant difference (p<0.05), post hoc test obtained significant differences in each group (p<0.05). There is an effect of moringa leaf ethanol extract on glycated albumin levels in white rats (Rattus norvegicus) model of diabetes mellitus induced by streptozotocin-nicotinamide.
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