Abstract
Antibody-dependent cell-mediated immune cytolysis of herpes simplex virus-infected target cells involves two separate events, recognition and adhesion of the effector K cells to the antibody-coated target cells, and the final killing step. In the present study the killing event is shown to be dependent on an intact secretory mechanism in the K cells. Treatment of K cells with the carboxylic ionophore monensin, which blocks secretion, completely abolishes the K-cell-mediated killing, but the adhesion of the effector cells to the antibody-coated target cells is not affected by monensin. The similarity between the killing events mediated by K and NK cells is discussed.
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