The effect of mobile phase composition on separation of some Non-Steroidal Anti-Inflammatory Drugs of the 2-arylpropanoic acid derivatives in System of Reversed-Phase Pressurized Planar Electrochromatography and High-Performance Thin-Layer Chromatography

Abstract

Separation of some Non-Steroidal Anti-Inflammatory Drugs, 2-arylpropanoic acid derivatives (naproxen, ketoprofen, fenbufen, indoprofen, fenprofen, flurbiprofen, ketorolac, carprofen) has been investigated with pressurized planar electrochromatography (PPEC) and high-performance thin-layer chromatography (HPTLC) in reversed-phase system.The mobile phase consisted of acetonitrile, and aqueous buffer. The influence of concentration of organic modifier in the mobile phase and the mobile phase buffer pH on migration distance (PPEC) and retardation factor (HPTLC) has been investigated and compared.