Abstract
The purpose . Previously it was shown that on-pump coronary artery bypass grafting (CABG) induced cerebral ischemia and cognitive decline. The patients with mild cognitive impairment (MCI) could be a high-risk group of CABG-associated cognitive decline. Non-invasive neuromonitoring can provide information regarding subclinical symptoms and topography of cerebral ischemia. The aim of this study was to investigate the topographic changes in electroencephalogram (EEG) spectral power in coronary artery disease (CAD) patients with or without MCI before and after on-pump CABG. Methods : 62 males with CAD were divided into two groups according to their Mini-Mental State Examination: without MCI (n = 37) and with MCI (n = 25). Clinical factors were assessed, including the severity of coronary lesions (SYNTAX score), the left ventricular ejection fraction (LVEF). Eyes-closed rest EEG was recorded from 62 channels positioned according to the International 10–20 system. Spectral EEG power was calculated for frequencies from 0.1 to 50 Hz. Results : The patients with MCI had theta-1 (4–6 Hz) power increase 7-10 days after on-pump CABG only in frontal and fronto-central clusters of right and left hemispheres as compared to the preoperative values, whereas in the groups without MCI this effect was widespread over the brain. In the beta-1 band (13–20 Hz), CABG patients with MCI had power increase in the frontal, fronto-central and fronto-temporal regions of the brain cortex. Similar power changes in patients without MCI were observed only for occipital brain clusters. Conclusions : CAD patients with MCI have demonstrated EEG signs of cortical dysfunction focused on the frontal brain areas. Cortical dysfunction in this localization can be associated with the progression of cognitive deficits, causing loss social integration in CAD patients with MCI.
Highlights
РАЗРАБОТКА ТКАНЕИНЖЕНЕРНОГО СОСУДИСТОГО ГРАФТА МАЛОГО ДИАМЕТРА THE EFFEДCЛTЯOНFУMЖДILСDЕCРOДЕGЧNНITОI-VСEОСIMУДPИAСIRТMОЙENХИTРOУNРГEИEИG TOPOGRAPHIC CHANGES AFTER ON-PUMP CORONARY ARTERY BYPASS GRAFTING
A statistically significant reduction in left ventricular ejection fraction (LVEF) was found 7–10 days after CABG compared to the preoperative data
Our study has found that CABG patients demonstrated EEG signs of brain dysfunction and damage in the postoperative period
Summary
РАЗРАБОТКА ТКАНЕИНЖЕНЕРНОГО СОСУДИСТОГО ГРАФТА МАЛОГО ДИАМЕТРА THE EFFEДCЛTЯOНFУMЖДILСDЕCРOДЕGЧNНITОI-VСEОСIMУДPИAСIRТMОЙENХИTРOУNРГEИEИG TOPOGRAPHIC CHANGES AFTER ON-PUMP CORONARY ARTERY BYPASS GRAFTING. Вithэкoспrеwриi-thout MCI ментах in vbitreofoдоreкаaзаnнdо,aчftтeоrрoоnст-оpвuыmе pфCакAтоBрGы., инкорпорируемые в состав биодеградируемых графтов, сохраняют свою биологическую актиMвнeоtсhтoь.dВs:д6ол2гоmсрaоleчнsыwхiэthкспCеAрDимwенeтrаeх dinivviidvoedдоiкnаtзoанtоw, oчтgоrсoоuсуpдsиaстcыcйorэdнiдnоgтеtлoиаtлhьeнiыr йMфinаiк-тMорenроtaстlаStуaскtоeрEяxетamination: эндотеКллиюзачцw(еSивiYюtыhNиеoTусAuллtXуочMвsшаcCа:oIебr(тиenпо)р=,доеt3хhгор7eда)идlaeмиnfроtdусеvтwмьeыniбtиеthrопiMдcоеuлCгиlрIaма(rдеneир=рыjeу,2еcс5мtоi)ысo.ухCnдпlиifосnrлтaiыиccмaйtiеloгрfрanнаcыф(tхLтo,VсrроEsосFwсу)тд.eоиErвсeyытeыеassхф-scгаeрlкosатsфsоeeртdоыdв,.i.rnecsltuEdEiGngwthase severity of coronary lesions recorded from 62 channels. TcEhcNoerTdpiFaOntOgFieRtnTotIsTSthHwSeEiUtIhnECtMeAErCnRNIaDGhtiIaoIONdnVEatAlhE1eSR0taC–E-2U1D0L(s4SAy–MsR6tAeHSmLzU.)LSRpDpoGeIwAcEetMRrraYEilnETcNErEGEeRaEpsDeoVwAS7e-S1rC0wUdaaLsyAcsaRlacfuGtelaRrtoeAdnF-fpTour mfrepqCuAeBnGcieosnflryomin frontal and fronto-centralLc.luVs.tAeNrsToOfNriOghVtAa, nYdUl.eAft. hKeUmDiRspYhAeVrTeSsEaVsAcompared to the preoperative values, whereas in the groups without MCI this effect was widespread over the brain. DCeorrtthiecalel addyesrsfuhinpcotfiothne iancathdeismlicoiacnaloizfaRtiAoSnLc.aSn. Bbaerbaasrsaoshciraetseedarcwhietshtothcerepatreogbiroeresssoiorbnabolef cognitive vascular prodstehfeicseitss,ocf asumsainll gdialomsestesrobceiaglainn. TtehgeraptrimonaryinpCurApoDsepa–titoenctresawteitpholMymCeIr. structures with bio-directed action capable to replace individuaKl setyruwctourredsso:f ma livldingcoorggnanitiisvme, inmppaarticrmulaer,notf,cEaErdGio,vtahsectualarhsystthemm.,Sccoierontnifiacrnyoavertlteyroyf tbhyepparosbslegmralifetsiningu,sSinYgNaTnAeXwscore. Approach for creation an organ directly in the patient’s body by biofunctional and bioresorbable features of polymer structures. The long-term patency of PCL vascular grafts and PHBV and PCL composition grafts had proved. Approach for creation an organ directly in the patient’s body by biofunctional and bioresorbable features of polymer structures. the long-term patency of PCL vascular grafts and PHBV and PCL composition grafts had proved. the in vitro experiments had proved that growth factors itnhcaot rvpaosKrcaeutyeladwr eoinnrtdodsoc:tohbmeiolipadolesggirtroiaowdnathobffleabcipotoodIrleynhmgatrerdardoasad,cbcauleevcleagtrsriaacotufentlsdareregntrdaaoinftth,teghlreiozirwatbtihoionflaoacgntiocdarhsl.aadctimiviptyr.oi3tvse9hcde]h.vleoaMmnsgcCiu-atleIararmipnsadinatemvncicvliyiolndoeifcxcbpaoioelgdritenmegirertmanivdtsaetbhhilaeamdtppdoienalymicmrlomeunrdsegternraasttfeti(sdnM. dCivIi)d[u1a8ls; Cardiovascular disease
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
