The Effect of Midazolam and Magnesium Sulfate on Preoperative Anxiety in Patients Undergoing Rhinoplasty Operation

Abstract

Introduction: Preoperative anxiety is a common psychological condition caused by many factors and can affect anesthesia results, postoperative analgesia, and surgery. This study investigated the effects of midazolam and midazolam combined with magnesium sulfate on preoperative anxiety. Materials and Methods: Sixty patients in the ASA I-II group, aged between 18-60 years, undergoing rhinoplasty operations were included in the study. Patients included in the study were randomly divided into two groups using the sealed envelope method. The first group (Group M; n:30) received 0.02-0.04 mg/kg midazolam in 100 ml isotonic, and the second group (Group MM; n:30) received 2g magnesium sulfate+0.02-0.04 mg/kg midazolam in 100 ml isotonic administered intravenously 15 minutes before surgery. In addition, state-trait anxiety inventory (STAI-TX) was evaluated preoperatively at 0. minutes and postoperative at 0., 3., 6. hours and the visual analog scale (VAS) was evaluated at 0., 3., and 6. hours postoperatively. Results: 66.7% were female (n:40), 56.7% were ASA-I (n:34), the mean age was 26.17±5.57(18-41) years, and the mean surgery time was 64±12.64 (35-90) minutes. There was no statistically significant difference between the groups regarding age, gender, ASA, and surgical duration of the cases. In addition, heart rate, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and VAS decreased compared to preoperative values, while TOF and STAI-TX values increased in both the M and the MM groups. Conclusion: Midazolam and midazolam-magnesium sulfate can be safe and effective for preoperative anxiety.