Abstract
Osseointegrated titanium implants have been widely used in clinics for replacement of missing teeth. However, sensory perception thresholds of implants were 10 to 100 times higher than those of natural teeth. The purpose of this study was to evaluate the effect of the ceramic coating generated by microarc oxidation (MAO) on sensory reconstruction around dental implants. The MAO coating was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and scanning probe microscope (SPM). Moreover, the chemical composition was analyzed with an energy dispersive spectroscope (EDS). Using smooth titanium discs as a control, Schwann cell responses to the coating were evaluated by SEM, MTT assay, total protein content and leakage of cytosolic lactate dehydrogenase (LDH) activity. In addition, the amount of brain-derived neurotrophic factor (BDNF) secreted by Schwann cells was measured by Enzyme-Linked Immunosorbent Assay (ELISA). It was observed that the porous coating had separated and homogeneous micropores in the diameter of 1-2 μm. The concentrations of Ca and P in the layer were 8.63% and 5.23% respectively. The cell morphology, proliferation and secretion of BDNF were unaffected. The results indicated that the MAO ceramic coating developed on the surface of pure titanium had good biocompatibility with Schwann cells for sensory reconstruction around dental implants.
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