Abstract
The present study, carried out in nine healthy male volunteers, investigated the effects of metoclopramide, ondansetron, and granisetron on gastric emptying of liquids, as assessed by the percentage cumulative fraction absorbed-time profiles of paracetamol. A single-blind, crossover, randomized design was followed that allowed at least a 2-week interval between study sessions. On each occasion, 1.5 g paracetamol was taken at zero time (6 AM). One of the following treatments was administered intravenously on four occasions at −30 minutes (5:30 AM): 8 mg ondansetron; 3 mg granisetron in 20 mL saline; 20 mg metoclopramide, by slow injection over 5 minutes; or 10 mL saline as placebo. The percentage cumulative fraction absorbed-time profiles of paracetamol were calculated from serial serum paracetamol concentration measurements using the Wagner-Nelson method. With granisetron pretreatment, significantly lower cumulative fractions of paracetamol were absorbed than after saline pretreatment at 120 minutes. The results suggest that in humans, granisetron—without additional pharmacologic effects—may retard gastric emptying, as it appears to be a more selective 5-hydroxytryptamine 3 antagonist than ondansetron or metoclopramide.
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