The effect of methanol extract of soybean (Glycine max L. Merr.) on rat testicular steroid hormones

Abstract

Soybeans contain phytoestrogens whose structure resembles estrogen in the body. Its function can be estrogen and antiestrogens, affecting the metabolism of sex steroid hormones. This study aims to determine the effect of soybean methanol extract on testosterone and estrogen levels in testicular rats. This study aims to determine the effect of soybean methanol extract on testosterone and estrogen levels in testicular rats. Twenty male Wistar rats were divided into 4 groups namely: control and treatment group were given soybean extract (250 mg/kg BW, 500 mg/kg BW) and genistein (0.3 mg/kg BW), respectively, for 52 days. The results of this research indicate that the effects of soybean methanol extract caused weight gain and decreased testicular weight. In addition, it showed that 500 mg/kg BW of soybean methanol extract reduced the level of testicular estrogen. It can be concluded that soybean methanol extract significantly reduced testicular estrogen levels for 52 days.