The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples.

Kristel Ehala-Aleksejev,Margus Punab,Joël R Drevet

doi:10.1371/journal.pone.0194395

Kristel Ehala-Aleksejev, Margus Punab + Show 1 more

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https://doi.org/10.1371/journal.pone.0194395

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Journal: PloS one	Publication Date: Mar 16, 2018
Citations: 23	License type: CC BY 4.0

Affiliation: Tartu University Hospital

Abstract

This study aimed to determine the effect of metabolic syndrome (MS) on the reproductive function in fertile (FM) and male partners of infertile couples (MPIC). We performed a cross-sectional study formatting two study groups: partners of pregnant women (n = 238; mean age 32.0) as FM and male partners of infertile couples (n = 2642; mean age 32.6) as MPIC. A standard semen analysis was performed and clinical, laboratory and lifestyle data were analysed. The adapted NCEP-ATPIII criteria were used to define MS. 12.2% of FM and 17.8% of MPIC had MS. In both groups, men with MS were older, they were centrally obese and had higher triglycerides, systolic and diastolic blood pressure and decreased HDL cholesterol values as compared to men without MS. However, glucose concentrations as well as fasting insulin levels were significantly higher only in the MPIC-MS+ group. MS was not associated with semen parameters. Testosterone levels were negatively correlated to MS in both groups. This negative association persisted within the BMI categories between MPIC-MS- and MPIC-MS+ groups. LH was negatively correlated to MS but only in MPIC. FSH and oestradiol were not correlated to MS. Smoking and alcohol consumption were higher among men with MS. This study shows that except for testosterone, MS has no independent effect on major fertility parameters in different subgroups of men.

Highlights

Metabolic syndrome (MS) is a complex of medical conditions characterized by abdominal obesity, dyslipidemia, hypertension and high fasting glucose
12.2% of fertile men’s group (FM) and 17.8% of male partners of infertile couples (MPIC) had MS according to the National Cholesterol Education Program (NCEP)-ATP III criteria for MS [14]
When stratifying FM and MPIC according to the presence or non-presence of MS, men with MS in both groups were centrally obese as indicated by increased Waist circumference (WC), Waist-toheight ratio (WHtR) and Body mass index (BMI) (Table 2)

Summary

Introduction

Metabolic syndrome (MS) is a complex of medical conditions characterized by abdominal obesity, dyslipidemia, hypertension and high fasting glucose. The worldwide prevalence of MS emerged as a predictor of cardiovascular disease and as a potential contributing factor to male infertility. A link between MS and lower general health status has been proved [1,2,3], an association between male infertility and MS is yet under discussion. There is strong evidence that MS is negatively associated with testosterone levels [2,3,4,5]] and might be positively related with plasma concentration of oestrogen [6].

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