Abstract
By manometric method using conventional Warburg apparatus, the oxygen uptake of rat brain homogenate in glucose, glutamate, and succinate was found to be inhibited by mescaline and yohimbine. Yohimbine inhibited the brain homogenate's respiration in glucose considerably more than it did the respiration in glutamate and in succinate. Mescaline inhibited the homogenate's oxygen uptake in glucose, in glutamate, and in succinate to a similar degree, when the drug and the substrate were added to the brain homogenate at the same time. This is in contrast to the lack of mescaline inhibition of the succinate respiration of chopped brain preparation which was incubated with the drug for two and one-half hours before addition of substrate, as reported by previous investigators.
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