Abstract
The effect of several mercurial compounds on ATPase activity of cell debris from rabbit kidney, has been examined in the light of recent evidence that certain ATPase systems are closely associated with sodium transport. The ATPase of kidney cell debris was found to resemble that of erythrocyte and nerve in its cation requirements. Organic mercurial compounds (Mersalyl, Merchloran, Esidrone and p-chloromercuribenzoate) preferentially inhibit the (Na + and K +)-stimulated portion of kidney ATPase activity, unstimulated activity being only slightly inhibited. Mercuric chloride has a preferential effect on the stimulated activity but strongly inhibits the unstimulated portion as well. Sulphydryl-reacting compounds iodoacetate and iodoacetamide do not inhibit ATPase nor do the diuretic compounds caffeine, theobromine, theophylline and chlorothiazide. The possibility that inhibition of ATPase is the cause of mercurial diuresis is discussed.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
