Abstract
Meprobamate (800 mg) depresses both respiratory and cardiovascular responses of men during exposure to neutral (80 °F, 26.7 °C) and cold (50 °F, 10.0 °C) environments. The inhibition of these responses is most severe during exposure to cold when the usual compensatory increases elicited by this stress are minimized. Drug-treated subjects effect only small increases in systolic and diastolic pressures during cold exposure and virtually no change in heart and respiratory rates. Although rectal temperatures of both drug and placebo groups decrease uniformly during exposure to a neutral environment, the subsequent increase stimulated by cold exposure is depressed in meprobamate-treated subjects. No differences in the hematocrit increase induced by cold exposure were detected between drug and placebo groups.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
