Abstract
Objective: The aim of this study was to determine the effect of mental health on health-related quality of life in adolescents.
 Methods: This cross-sectional study was conducted among 1188 students studying in a public high school in Istanbul, Turkey. Data were collected using the General Health Questionnaire (GHQ-12) and the Turkish Generic Health-Related Quality of Life Questionnaire for adolescents (Kiddo-KINDL). Descriptive statistics, correlation analysis and multiple regression analysis were used in the analysis.
 Results: The mean age of the adolescents was 16.61±1.17; 56.6% were female. This study shows that mental health was a negatively significantly related to all subscales of health-related quality of life (physical wellbeing, emotional wellbeing, self-esteem, family, friends, school) of adolescents (p
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