Abstract

Pulmonary cell membranes form the first line of defense against respiratory viral infections and play an important role in modulating immune responses to airborne pathogens, such as the recent coronavirus (SARS-COV-2). Interestingly, common drugs, such as azithromycin and melatonin, have been reported as potential agents in slowing down and ameliorating the symptoms of respiratory viral infections, including SARS-COV-2. The generic effects of these drugs, across a range of viral infections, point to an indirect mechanism by which they inhibit viral activity - most likely by altering membrane properties and perturbing viral membrane-entry pathways.

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