Abstract
Muscle activity during a hemodialysis procedure improves its efficacy. We have formulated a hypothesis that vibrations generated by a specially-designed dialysis chair can, the same as physical exercise, affect the filtering of various fluids between fluid spaces during the hemodialysis procedure. This prospective and interventional study included 21 dialyzed patients. During a single dialysis session, each patient used a prototype device with the working name “vibrating chair”. The chair’s drive used a low-power cage induction motor, which, along with the worm gear motor, was a part of the low-frequency (3.14 Hz) vibration-generating assembly with an amplitude of 4 mm. Tests and measurements were performed before and after the vibration dialysis. After a single hemodialysis session including five 3-min cycles of vibrations, an increase in in relation to non-vibration ( vs. ) was seen. Urea reduction ratio increased significantly ( vs. ). A significant increase in systolic blood pressure was observed between the first and the third measurement ( vs. ). The use of a chair generating low-frequency vibrations increased dialysis adequacy; furthermore, it seems an acceptable and safe alternative to intradialytic exercise.
Highlights
Dialysis therapy, as a method of renal replacement in end-stage renal disease (ESRD), is based on removal of excessive and toxic metabolic products from the intravascular water space [1,2]
The dialysis dose based on Kt/V and urea reduction ratio (URR) measurements is related to patients’ quality of life and might be considered a factor that influences the morbidity of hemodialyzed patients [15,16,17]
Some believe that Kt/V is an inadequate measure of adequacy, it seems to be the value most associated with dialysis patients [20]
Summary
As a method of renal replacement in end-stage renal disease (ESRD), is based on removal of excessive and toxic metabolic products (uremic toxins) from the intravascular water space [1,2]. One of the obstacles in the efficacy of hemodialysis (HD) is the inefficient exchange of uremic toxins and other filterable substances between extracellular intravascular and extravascular fluid, as well as between extravascular extracellular and extravascular intracellular fluid [3,4]. Previous research has shown that muscle activity during a hemodialysis procedure improves its efficacy [5,6,7]. Despite reports on the effects of vibrations on the skeletal, muscular, and cardiovascular systems [8,9,10,11], the effect of vibrations on hemodialysis remains undetermined. Public Health 2019, 16, 594; doi:10.3390/ijerph16040594 www.mdpi.com/journal/ijerph
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