Abstract
Obstruction at the pylorus was induced in dogs with Pawlow double stomachs, by passing a silver band around the pylorus and regulating the constriction so as to narrow but not entirely occlude the pyloric lumen. The effects of this operation upon gastric secretion were primarily: (1) A diminution in the amount of gastric juice secreted in the first two hours after taking food, that is, there was a decrease in the amount of appetite juice. (2) The digestive period was much prolonged, a copious secretion continuing into the seventh and eighth hours, when, under normal conditions with the same foods, no secretion took place after the fourth hour. (3) There was a constant secretion of gastric juice without regard to the time of the last feeding and having no apparent relation to whether the stomach contained food or was empty, and also (4) a marked hypertrophy of the muscle coats of the stomach at the pyloric end, with moderate dilatation of the cardiac portion.
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