Abstract

The effects on foetal growth of administering allyl formate or aflatoxin B 1 or of feeding a restricted diet to the pregnant rat have been studied. A significant retardation of foetal growth occurred in rats given allyl formate (0·15 ml/kg) by intubation on day 19 of pregnancy and in rats developing grade II liver lesions (extensive fatty infiltration, biliary proliferation and persistent cell necrosis) following similar administration of 5–7 mg aflatoxin B 1/kg on day 16. Paired-feeding experiments with untreated animals demonstrated that the reduction of foetal growth was related primarily to the dietary intake of the pregnant rat and only indirectly to the severity of the maternal liver lesion.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.