The Effect of Maternal Ingestion of Iophenoxic Acid on the Serum Protein-Bound Iodine of the Progeny

Abstract

IN 1957 Astwood1 reported markedly elevated levels A of serum protein-bound iodine (2000 to 14,000 microgm. per 100 ml.) in a group of patients who had received by mouth a cholecystographic medium, iophenoxic acid [3-(3-hydroxy-2,-4,-6-tri-iodophenyl)2-ethyl propionic acidj.‡ Furthermore, the abnormal iodine values persisted for an inordinately long period — that is, semilogarithmic plotting of the original data indicated that it would take thirty-three years for the level to fall to 1 microgm. per 100 ml. after ingestion of the usual dose of iophenoxic acid (3.0 gm.). The prolonged great elevation of the protein-bound iodine from this medium has been amply . . .