Abstract
A study of the healing of peritoneal defects in the rat in the presence of the Walker 256 tumour has been made. The healing process was investigated histologically, by autoradiography, and by hydroxyproline estimation of the healing peritoneal wound. There was no difference in the rates or quality of the healing process in the control or tumour bearing animals.
Highlights
SEVERAL surveys of factors responsible for the rupture of laparotomy wounds have indicated that malignant disease is important in this respect (Tweedie and Long, 1954; Alexander and Prudden, 1966; and Guiney et al, 1966)
The healing process has been examined by histological studies of peritoneal defects in serially sacrificed animals, and collagen synthesis by autoradiography following the injection of tritiated proline and by hydroxyproline estimation of the healing defect
Adequate peritoneal healing would seem to be an important feature of normal healing of the abdominal wound
Summary
SEVERAL surveys of factors responsible for the rupture of laparotomy wounds have indicated that malignant disease is important in this respect (Tweedie and Long, 1954; Alexander and Prudden, 1966; and Guiney et al, 1966). Most conclude that the effect is due probably to indirect factors in patients with neoplastic disease (vitamin and protein deficiency, and malnutrition in patients in the older age group) rather than a specific inhibition of the healing process. Of relevance to patients with advanced malignant disease, it has been demonsstrated that protein deficiency (Mott et al, 1969), uraemia (Mott and Ellis, 1967), vitamin C deficiency (Ellis et al, 1965), and local x-ray therapy (Venables et al, 1967) impaired the fibroblastic proliferation in peritoneal defects and the subsequent healing process. Measurements were made of weight loss and haemoglobin and plasma protein levels in the animals
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