THE EFFECT OF MAGNESIUM SULPHATE ON LIDOCAINE EPIDURAL ANALGESIA IN GOATS

Mohamed H El-Daharawy ,Ibrahim E Helal

doi:10.21608/avmj.2012.173771

Abstract

Five adult baladi goats were used to evaluate the effect of different doses of magnesium sulphate (MgSo4) that were injected epidurally in combination with lidocaine Hcl 2% on the duration and area of analgesia as well as side effects. Animals were treated as follow: treatment I was injected with lidocaine Hcl 2% (1 ml/7 kg). Treatments II, III and IV were injected with lidocaine Hcl 2% (1 ml/7 kg) in combination with 25, 50 and 100 mg MgSo4 10%, respectively. Results revealed that onset of analgesia was delayed in treatments II, III and IV (3, 3.5 and 3.5 minute, respectively). Treatment IV produced the longest duration of analgesia (99.80 ± 2.35 min). There was a significant increase in the animal recumbency in treatment I as compared to other treatments. The extent of analgesic area was almost the same in all treatments that extended from perineum to T13. Ataxic effect recorded in different patterns in treated animals. Treatment I had the longest duration of recumbency followed by mild ataxia in treatment II. In other treatments, ataxia was not developed. In conclusion, the combination of 2% lidocaine with 100 mg MgSo410% injected epidurally in goats resulted in prolonged duration of analgesia extending from the perineum to the flank region without ataxia, cardiovascular or respiratory side effects.

Highlights

Ruminants are generally not considered good subjects for general anaesthesia mainly because of the hazards of regurgitation and inspiration pneumonia
Epidural analgesia is usually produced by local analgesic which usually lidocaine Hcl 2% solution (Hall et al, 2001)
Lumbosacral epidural analgesia was produced in all treatments

Summary

INTRODUCTION

Ruminants are generally not considered good subjects for general anaesthesia mainly because of the hazards of regurgitation and inspiration pneumonia. Epidural analgesia is usually produced by local analgesic which usually lidocaine Hcl 2% solution (Hall et al, 2001). Epidural administration of agents with greater duration of action is proper for procedures requiring long duration of analgesia. The main objective of current research is to evaluate the effect of the different doses of MgSo4 injected epidurally combined with lidocaine Hcl 2 % in goats. Chemicals Co. for Al-Debeiky Pharma A.R.E.) and 1 ml preservative free sterile water while treatments II, III and IV were injected by using lidocaine Hcl 2% (1 ml/7 kg) combined with 25, 50 and 100 mg MgSo4 10% All animals received a standard painful stimulus with 23-gauge, 2.5-cm needle In this way, the presence and the anatomic extend of the analgesia was determined. Scale 0 indicated that response was detected after superficial skin prick (no analgesia).

RESULTS

IV Total

DISCUSSION