THE EFFECT OF MAGNESIUM DEFICIENCY ON OXIDATIVE PHOSPHORYLATION

J.J Vitale,M Nakamura,D.M Hegsted

doi:10.1016/s0021-9258(18)70643-1

Abstract

THE EFFECT OF MAGNESIUM DEFICIENCY ON OXIDATIVE PHOSPHORYLATION

Highlights

More recently we have shown that high levels of dietary magnesium completely prevent the uncoupling effect on heart mitochondria of thyroxine-fed animals, and partially overcome the growth inhibition caused by thyroxine
These observations suggested that magnesium deficiency alone might produce a similar uncoupling of oxidative phosphorylation
The P:O ratio for heart mitochondria was further decreased after 8 days on the deficient diet and a similar value was obtained after 11 days

Summary

OXIDATIVE PHOSPHORYLATION”

The gross signs observed in the thyroxine-treated animals were in many respects similar to those seen in magnesium deficiency [6]. These observations suggested that magnesium deficiency alone might produce a similar uncoupling of oxidative phosphorylation. The mitochondria of cardiac tissue are much more sensitive to the effects of thyroxine administration and magnesium deficiency than are those of liver and kidney. Per cent of Mg. In acute experiments, rats receiving the control diet containing 24 mg. Mitochondria of the heart, kidney, and liver were prepared and the oxidative phosphorylation efficiency was determined as described previously [6]. The phosphorus determinations were carried out by the method of Taussky and Shorr [7]

AND DISCUSSION

Time after injection

SUMMARY