Abstract
Abstract Intravenous injection of KHT sarcoma cells into syngeneic C3H mice produces tumour nodules or colonies the number of which is directly proportional to the number of viable cells injected. Localized irradiation of the lungs prior to cell injection was found to increase the number of lung colonies arising from the injection of a given number of tumour cells. This increase was (a) dose-dependent, (b) transitory in nature, and (c) resulted from a reduced clearance of viable tumour cells from the capillaries of the lungs.
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