Abstract
Problem statement: The goal of the current investigation was to clarify the effects of Citrullus colocynthis pulp extract on the structure of the liver of diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino rats were equally allocated into four groups: Group1: control, Group 2: Citrullus colocynthis-treated, Group 3: diabetic rats and Group4: diabetic rats treated with Citrullus colocynthis. All treatments were administered via an intragastric tube. Diabetes was induced in the rats of groups 3 and 4 by an intraperitoneal injection with alloxan. Results: The liver of Citrullus colocynthis-treated rats revealed minor histological changes versus the control animals. In group 3 animals, diabetes caused degenerative alterations in the form of disorganization of the hepatic cords, cytoplasmic vacuolization and pyknosis of the nuclei of hepatocytes and inflammatory cell infiltration. Scanning electron microscope examination of these livers revealed numerous lipid droplets within hepatocytes, damaged blood sinusoids and hemorrhage of erythrocytes between hepatocytes and inside Disse's spaces. On the other hand, the normal histological and scanning ultrastructural features were nearly resumed in the liver of diabetic rats treated with Citrullus colocynthis pulp extract. Conclusion: The present study proved a lessening effect of Citrullus colocynthis pulp extract on the liver of diabetic rats. In light of these advantageous influences, it is advisable to widen the scale of its use in a trial to alleviate the diabetic hepatic adverse effects.
Highlights
Diabetes mellitus is a chronic metabolic disorder characterized by widespread complications
Data shows normal hepatic index in normal rats treated with Citrullus colocynthis as compared to normal rats given normal saline
Diabetic rats treated with Citrullus colocynthis showed a significant decrease in this hepatic index when compared to their control diabetic rats
Summary
Diabetes mellitus is a chronic metabolic disorder characterized by widespread complications. Citrullus colocynthis (cucurbitaceae), commonly known as “bitter apple”, “colosynth”, “vine-of-sodom” and “tumba” is a tropical plant that grows abundantly in Company Inc., St Louis, MO, USA), in a dose of 150 mg kg−1 body weight, dissolved in normal saline Since this drug is capable of producing initial fatal hypoglycemia as a result of the massive pancreatic insulin release, the animals were treated with 30%. Experimental design: Forty-eight adult male albino the notion of the present investigation arose and was rats were used in the current study They were accomplished with an intent to throw light on these categorized into four groups, twelve animals in each effects utilizing both the light and scanning electron (n = 12). Results were subjected to the test for significance and were considered statistically significant at p≤0.05 according to Daniel (1987)
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