Abstract
Introduction: In this study, the aim was to evaluate the effect of low-level laser therapy (LLLT) on quality of life in postmastectomy lymphedema (PML) patients.
 Methods: Twenty-four female patients diagnosed with PML were included in the study. Demographic features, disease and lymphedema duration, cancer type, cancer stage, operation type, radiotherapy and chemotherapy history, lymphedematous and dominant extremity, and body mass index (BMI) were recorded. LLLT was applied to the affected limb as 904 nm, 1.5 Joule/cm2, three days a week for a total of 8 weeks. Quality of life assessment, lymphedema severity, and lymphedema staging was performed to measure effectiveness before and after treatment. Patients with lymphedema not associated with breast cancer and/or primary lymphedema, ongoing radiotherapy, metastatic high-grade breast cancer, acute infection, and deep vein thrombosis were excluded from the study.
 Results: Modified radical mastectomy was reported in 18 patients; total mastectomy and sentinel lymph node biopsy were reported in 6 patients. Of the patients, 45.8% were stage 3, and 54.2% were stage 2. Of the patients, 95.8% had a history of chemotherapy and 83% of radiotherapy after surgery. In this study, following LLLT, improvement of lymphedema stage and severity were found to be statistically significant (p < 0.05). In the evaluation of lymphedema quality of life, there was a statistically significant improvement in parameters including function, appearance, clinical symptoms, and overall quality of life (p < 0.05). However, no improvement was observed in the emotional state parameter (p > 0.05). 
 Conclusion: Thus, LLLT is a safe treatment method that increases the quality of life in breast cancerrelated lymphedema patients.
Highlights
In this study, the aim was to evaluate the effect of low-level laser therapy (LLLT) on quality of life in postmastectomy lymphedema (PML) patients
Patients with lymphedema not associated with breast cancer and/or primary lymphedema, ongoing radiotherapy, metastatic high-grade breast cancer, acute infection, and deep vein thrombosis were excluded from the study
The purpose was to show the effect of LLLT on clinical symptoms, functional status, and quality of life in patients with lymphedema that develops after breast cancer-related surgery
Summary
Breast cancer is the most important cause of cancer-related mortality among women 1. Radiotherapy, chemotherapy, and hormonal therapy reduce breast cancer mortality rates, each can cause different side effects. The purpose was to show the effect of LLLT on clinical symptoms, functional status, and quality of life in patients with lymphedema that develops after breast cancer-related surgery. The effect of low-level laser therapy on quality of life in postmastectomy lymphedema patients. Biomedical Research and Therapy, 7(9):3971-3976 ages, education levels, body mass index (BMI; kg/m2), disease and lymphedema durations, cancer stages, operation types, history of chemotherapy and radiotherapy, as well as lymphedema-affected and dominant limb and shoulder range of the patients were recorded. The Lymphedema Quality of Life Survey (LYMQOL-Arm) that had Turkish validity and reliability was applied to the patients to measure the effectiveness of the treatment 10. The data obtained before and after the laser treatment were compared using the Wilcoxon-Signed test, which is a comparison method of non-parametric dependent two groups; p < 0.05 was considered as significant
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