The effect of low power Laser therapy upon hepatocyte permeability in elderly patients with postraumatic and osteoarticular degenerative pathologies

Abstract

Event Abstract Back to Event The effect of low power Laser therapy upon hepatocyte permeability in elderly patients with postraumatic and osteoarticular degenerative pathology Cristian R. Revnic1*, Nicolae Teleki2, Gabriel Prada3, Speranta Prada1, Catalina Pena3 and Floarea Revnic3 1 University of Medicine and Pharmacy”Carol Davila”, Romania 2 National Institute of Physical Medicine,Rehabilitation and Balneoclimatology, Romania 3 National Institute of gerontology and Geriatrics”Ana Aslan”, Romania Introduction: There is an increasing interest of medical world regarding demonstration and support of local and general therapeutical effects of Laser therapy. Aim of the study: To see to what extent biostimulation with Low power Laser induces modifications in hepatocyte permeability in humans. Materials and methods: 100 patients aged 30–75 years old, 45 with Scapulohumeral periarthritis (SHP), and 55 with bilateral gonarthrosis, admited in Rehabilitation Clinique have been divided into two groups of 50 patients each: group A (control) with drug and physiokinetic therapy only, and group B with the same treatment plus biostimulation with Low power Laser GaA/As(1-6J/cm2). Modification of hepatocyte permeability has been recorded, by determining differences in haemathologic concentrations of L-aspartateaminotranspherase (AST) and L-alanylaminotranspherase (ALT) on the first and 12th day of treatment. Results: In group A there was an increase in AST values, which accounts for an increase in hepatocytolysis on the 12th day (in comparison with 1st day the mean difference was +0.7 (p<0.09). In group B there was a respective reduction in hepatocytolysis, with a reduction in AST values on the 12th day (in comparison with 1st day of treatment, the mean difference was -5.3u/l (p<0.002), accounting for a protective effect of Laser biostimulation with reduction of hepatocytolysis and hepatocyte permeability. Comparing the values of ALT in the two groups, there was a net statisticaly significant difference between mean values from the 12th day comparing to those of the 1st day, of -5.9u/l (p<0.001). These aspects underline that drug and physiokinetic therapies do not influence significantly hepatocyte permeability. Association of biostimulation with GaA/As Laser in those patients reduces significantly hepatocyte permeability on the 12th day of treatment. By this effect we can suggest the protective effect of biostimulation with low power Laser upon hepatocyte permeability and upon hepatocytolysis. In group B De Rits coeficient varied from 1.2 on the first day of treatment to 1.37 on the 12th day. Conclusions: Low power Ga A/As Laser biostimulation leads to a decrease in AST and ALT levels, reducing hepatocyte permeability and hepatocytolysis, with increasing De Rits index. Keywords: Laser Therapy, biostimulation, hepatocyte permeability Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Poster Topic: Novel techniques in xenobiotic studies Citation: Revnic CR, Teleki N, Prada G, Prada S, Pena C and Revnic F (2010). The effect of low power Laser therapy upon hepatocyte permeability in elderly patients with postraumatic and osteoarticular degenerative pathology. Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00189 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Oct 2010; Published Online: 04 Nov 2010. * Correspondence: Dr. Cristian R Revnic, University of Medicine and Pharmacy”Carol Davila”, Bucharest, Romania, kityrom@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Cristian R Revnic Nicolae Teleki Gabriel Prada Speranta Prada Catalina Pena Floarea Revnic Google Cristian R Revnic Nicolae Teleki Gabriel Prada Speranta Prada Catalina Pena Floarea Revnic Google Scholar Cristian R Revnic Nicolae Teleki Gabriel Prada Speranta Prada Catalina Pena Floarea Revnic PubMed Cristian R Revnic Nicolae Teleki Gabriel Prada Speranta Prada Catalina Pena Floarea Revnic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.