Abstract
The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of non-lethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.
Highlights
Selenium (Se) is an essential trace element and has important roles in the redox regulation system in our body
The major visible abnormalities of our SeD model rat were ateliosis, alopecia, and aggressiveness, which are found in the deficiency of other minerals and are not specific to Se-deficiency
Since similarity between SeD and vitamin E deficient rats to the changes in Fe and Zn contents in several organs were shown in the previous report [2], uptake of redox-related minerals, including Zn, into the tissue may change as a response to oxidative stress
Summary
Selenium (Se) is an essential trace element and has important roles in the redox regulation system in our body. Molecules 2009, 14 results in the depression of glutathione peroxidase (GSH-Px) activity and is believed to cause various forms of oxidative stress [3]; roles and/or amount of biometals working in the in vivo redox regulation system, such as iron (Fe) and zinc (Zn), may modify oxidative stresses. Fe accumulations in several organs of the SeD rat have been reported [1,2,4,5,6]; the Fe levels appear to be dependent on the age of the SeD rat [6]. The dependence of rat age on Se, Fe, and Zn levels in the liver, kidney, and spleen were measured and compared using instrumental neutron activation analysis (INAA). The effect of age-dependent oxidative stress on mineral balances in rat tissues/organs was discussed
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