The effect of long-term administration of chondroitin sulfate on the functioning of the reproductive system of male rats

Abstract

We assessed the effect of chondroitin sulfate in dose of 60 mg/kg during the period of spermatogenesis (the time between the first division of the spermatogonium and the sperm ejaculation from the testes), including the term of ripening in the epididymis — 70 days. Prolonged administration of chondroitin sulfate has no negative effect on the processes of spermatogenesis, especially on young cells of the spermatogenic epithelium — spermatogonia, and does not increase the number of tubules on the 12 stages of meiosis, that is, it does not reduce the reserve of spermatogenesis. Our findings testify, that the administration of chondroitin sulfate has no negative effect on the level of androgenic saturation and the functioning of the reproductive system of male rats.