The effect of local white turmeric (Curcuma Zedoaria) on the uterus surface profile of white rats (Rattus novergicus) with ethinyl estradiol induction

Abstract

Background: White turmeric rhizome (Curcuma Zedoaria) contains important compounds for traditional medicine and the pharmaceutical industry. The variation in the benefits of white turmeric is thought to be due to the compounds in the rhizome, significantly compounds with antioxidant activity. Purpose: Determine the effect of local varieties of white turmeric in Sambori Bima Village, West Nusa Tenggara, Indonesia, on the uterine surface profile of white rats (Rattus Novergicus) induced by Ethinyl Estradiol. Methods: This research uses 25 white rats divided into five treatment groups, namely control (-) not given Ethinyl estradiol or white turmeric extract, control (+) is given Ethinyl estradiol at a dose of 150mg/kg BW (Body Weight)/day without white turmeric extract. P1, P2, and P3 treatment were given Ethinyl estradiol at a dose of 150mg/kg BW/day and white turmeric extracts with diffferent concentration. P1 was given white turmeric extract 500mg/Kg BW/day, P2 was given white turmeric extract 750mg/Kg BW/day, P3 was given white turmeric extract 1000mg/kg BW/day. White turmeric extract was examined using GCMS, and uterine organs were taken for histopathological preparations. Results: Methanol extract of white turmeric contains compounds including [2.2.1] heptan-2-ol, exo-β-element, sesquiterpene, Gremacrene, Epiglobulol, Spathulenol, Eudesmol and, Germacrone. Histopathological analysis shows the different distances between glands in the endometrial. Hyperplasia of the gland occurred on all treatments except for P3 (1000 mg/kg BW). Conclusion: Administration of white turmeric extract with eight beneficial health compounds could stop the artificial proliferation of Ethinyl estradiol for 14 days plus 30 days.