Abstract
BackgroundLiver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats.MethodsAlbino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals.ResultsIncreased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically.ConclusionsLiv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.
Highlights
Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it
The aim of our study is to examine the effect of Liv-52 on the liver damage induced by I/R in rats biochemically and histopathologically
Biochemical results Effect of Liv-52 supplementation and I/R on liver enzymes As showed in Fig. 1, the Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Lactate dehydrogenase (LDH) activities used in evaluating the liver functions were increased in I/R group compared to healthy group and there was a statistically significant difference (p < 0.001) between them
Summary
Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Hepatic portal occlusion operation or Pringle maneuver interrupting portal vein and hepatic artery entries are temporarily performed to control bleeding control during operations such as liver resection, transplantation and hepatobiliary surgery [1]. This method is widely used since it is clinically simple, practical and effective. This methodology can lead to a significant risk of liver damage due to ischemia reperfusion (I/R) [2].
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