Abstract
Tetramethylpropyleneamine oxime (TMPAO) was synthesized and complexed to 99mTc. 99mTc-TMPAO samples, when challenged with reduced glutathione (GSH), were shown to have two GSH sensitive components, similar to a mixture of d, l and meso 99mTc-HMPAO. One component had a GSH-induced second-order dissociation rate constant ( K 2) similar to 99mTc-meso-HMPAO. Despite the presence of a large fraction of this component in these samples, brain uptake and autoradiographic studies with 99mTc-TMPAO were equivalent to 99mTc- d,l-HMPAO suggesting that both the d, l and meso 99mTc-TMPAO isomers are efficiently trapped in brain.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
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