Abstract
The effects of Li + on NaCa exchange in bovine cardiac sarcolemmal vesicles were examined. The initial rate of Na +-dependent Ca 2+ uptake and efflux was inhibited by Li + in a dose dependent manner. The initial rate of Na +-dependent Ca 2+ uptake was inhibited 49.8±2.9% (S.E.) (n=6) in the presence of Li + compared to activity in external K + or choline +. Kinetic analysis indicated that Li + increased the Km for Ca 2+ (96.3 μM) compared to K + and choline + (25.5 and 22.9 μM respectively) while Vmax (1.4, 1.2 and 1.1 nmol Ca 2+/mg protein/sec respectively) remained unchanged. Li + did not alter the experimentally derived stoichiometry of the exchange reaction of 3 Na + for 1 Ca 2+.
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