The effect of levonorgestrel-releasing intrauterine system on IGF-I and IGF-IR expression after transcervical resection of polyp

Abstract

Objective To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on insulin-like growth factor-I (IGF-I) and insulin-like growth factor-I receptor (IGF-IR) expression after transcervical resection of polyp (TCRP). Methods 100 cases of endometrial polyps were selected. The control group (n=50) was treated with TCRP only, while the observation group (n=50) was treated with LNG-IUS after TCRP. The scores of pictorial blood loss assessment chart (PBCA), endometrial thickness, recurrence rate, mRNA expression of IGF-I and IGF-IR in endometrial tissue were compared between the two groups. Results At 1, 3, 6, 12 months follow-up, the PBAC score and endometrial thickness of observation group were significantly lower than control group (P<0.05). At 12 months after operation, the mRNA expression levels of IGF-I and IGF-IR in the endometrium of the observation group were significantly lower than those of the control group (P<0.05). After 12 months of follow-up, the recurrence rates of the control group and the observation group were 16.0% (8/50) and 4.0% (2/50), respectively. The recurrence rate of the observation group was significantly lower than that of the control group (P<0.05). Conclusions TCRP combined with LNG-IUS treatment can significantly reduce EP recurrence, and down-regulation of the mRNA expression of IGF-I and IGF-IR maybe its possible mechanism. Key words: Levonorgestrel; Intrauterine devices, medicated; Endometrial polyp; Hysteroscopy; Insulin-like growth factor I; Receptor, IGF type 1