The effect of levo-thyroxine, dextrothyroxine and levo-tri-iodo-thyronine on the electrocardiogram in myxedema: preliminary report.

Abstract

Article1 March 1955THE EFFECT OF LEVO-THYROXINE, DEXTRO-THYROXINE AND LEVO-TRI-IODO-THYRONINE ON THE ELECTROCARDIOGRAM IN MYXEDEMA: PRELIMINARY REPORTPAUL STARR, M.D., F.A.C.P., RUTH LIEBHOLD-SCHUECKPAUL STARR, M.D., F.A.C.P.Search for more papers by this author, RUTH LIEBHOLD-SCHUECKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis preliminary report concerns the beginning of a study of the action of thyroxine on the heart. Its effects are so powerful and beneficial in the case of the heart of the hypothyroid patient that its therapeutic value in other kinds of heart disease should be determined. This will require a careful analysis of the pharmacology of thyroxine, to which these observations are a brief introduction. This seems to be the obverse of the therapeutic induction of hypothyroidism in heart disease that is now being advised.Death during the first few days of the treatment of myxedema with desiccated thyroid...Bibliography1. Means JH: The thyroid and its diseases, 2nd Ed., 1948, J. B. Lippincott Co., Philadelphia. Google Scholar2. AsherFlach LM: Beitrage zur Physiol. der Drusen, Ztschr. f. Biol. 55: 83, 1911. Google Scholar3. LewisMcEachern JKD: Persistence of accelerated rate in isolated hearts of thyrotoxic rabbits; response to iodides, thyroxine and epinephrine, Bull. Johns Hopkins Hosp. 48: 228, 1931. Google Scholar4. EppingerFaltaRudinger HWC: Über die Wechselwirkungen der Drüsen mit innerer Sekretion, Zentralbl. f. d. ges. Physiol. u. Path. d. Stoffwechs. 3: 810, 1908. Google Scholar5. BrewsterIsaacsOsgood WRJPPF: Relationship of L-thyroxine to cardiovascular, calorigenic and metabolic effects of L-epinephrine and L-norephinephrine, Federation Proc. 13: 559 (Mar.) 1954. Google Scholar6. StewartDeitrickCrane HJENF: Studies of the circulation in patients suffering from spontaneous myxedema, J. Clin. Investigation 17: 238 (May) 1938. CrossrefGoogle Scholar7. StarrLiebhold-Schueck PR: Effect of oral thyroxine and tri-iodo-thyronine on radioactive iodine uptake and serum protein bound iodine in normal human subjects, Proc. Soc. Exper. Biol. and Med. 83: 52-54, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Presented as a Morning Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 9, 1954.†Supported in part by Baxter Laboratories, Morton Grove, Illinois, U. S. Public Health Service (Grant No. C-1214(C3)), and Smith, Kline and French Foundation.From the Thyroid Clinic of the Los Angeles County Hospital and The Department of Medicine of the School of Medicine, University of Southern California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCongestive Heart Failure in Infancy due to HypothyroidismSchilddrüsenhormonanaloge und -metaboliten unter besonderer Berücksichtigung ihrer klinischen AnwendungElectrocardiographic changes following the administration of thyroid stimulating hormone (thyrotropin)∗Das Herz bei Myxödem und Hypothyreose 1 March 1955Volume 42, Issue 3Page: 595-606KeywordsCardiovascular therapyElectrocardiographyHeartHospital medicineHypothyroidismLongitudinal studiesMedical servicesPharmacologyThyroidThyroxine ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...