Abstract
The imidazolate-zeolite framework-8 (ZIF-8), as a zinc-based metal-organic framework, can act as an antibacterial agent by releasing Zn2+ ions. In this project, utilizing this previously studied fact, a set of wound dressings has been prepared using polycaprolactam and polylactic acid. Electrospinning and electro-spraying processes have been employed to create these samples. In total, five samples were obtained with variations in the layering sequence, and all samples were tested against two bacteria: Staphylococcus aureus and Escherichia coli. The results indicated that all samples were effective against the Gram-positive bacterium S. aureus, with the sample produced by simultaneous electro-spraying and electrospinning exhibiting the highest lethality rate. However, only the sample with the sequence of polycaprolactam layer, polylactic acid, and then ZIF-8 succeeded in eliminating 99% of E. coli. The produced products were characterized using powder X-ray diffraction, IR spectroscopy, and scanning electron microscopy. The antibacterial effect of these wound dressings was evaluated using direct counting of bacterial colonies.
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