The effect of laparoscopic radical nephrectomy on postoperative pain and related blood indices

Abstract

Objectives To observe the differences of postoperative pain and blood indicators in laparoscopic radical nephrectomy and open radical nephrectomy for patients. Methods 80 patients in our department from May 2012 to May 2015 were selected, who were randomly divided into control group and observation group, 40 patients in each group. The patients in control group underwent open radical nephrectomy, the observation group accepted laparoscopic radical nephrectomy., The VAS score, factor level; serum stress-related indicators (white blood cell count, serum cortisol, thyroxine and CRP), tumor markers (CA50, CEA, CA125) and inflammatory cytokines of the two groups were compared before and after operation. Results There was no significantly difference in the VAS score and 5-HT level of the two groups before operation. The VAS score and 5-HT levels were significantly higher than those before surgery on the 3rd day postoperatively, but the observation group was less than the control group (P<0.05). The preoperative stress parameters in the two groups had no difference, the number of leukocytes, cortisol, CRP levels of control group were higher than that in the observation group after 3 days, while the levels of FT3 and FT4s were lower than observation group. The level of IL-2 of observation group was higher than control group, but the levels of IL-10 and IL-13 were lower than the control group, and the levels of pro-inflammatory cytokines IL-1β, IL-6 and IL-12 were lower than the control group (P<0.05). Conclusions Compared with open radical nephrectomy, laparoscopic radical nephrectomy not only can ensure the cancer removed, and less impact on the body's inflammatory equilibrium state, reduce the body's response to oxidative stress, which can reduce postoperative pain and promote the early resumption of the body for patients. Key words: Kidney Neoplasms; Laparoscopes; Pain