The effect of lansoprazole injection on 24-hour intragastric pH in healthy volunteers

Abstract

Objective To investigate the effect of lansoprazole injection on 24-hour intragastric pH in healthy volunteers. Methods The volunteers inclouding 10 women and 10 men, were divided into experitmental group and control group randomly, each group of 10 cases. After testing the pH initial value in stomach through pH determination electrode, the cases in experitmental group were drip the drug of lansoprazole injection, the cases in control group were drip the same volume of 0.9% sodium chloride solution. Then constantly determined the value of pH in the stomach for 24 h. Results The pH value in the stomach of expertimental group after injected lansoprazole was significantly higher than that before administration (P < 0.05). The pH value in the stomach of expertimental group was higher than that in control group between finished of injection and 24 h, especially in the first 12 h after administration, there were significantly differences (P < 0.01). The pH value in experimental group after injected lansoprazole for 24 h was 4.565±1.109, in control group was 2.211±0.263, there was significant difference (P < 0.01). The percentage of maintenance time of pH reaching 4.0 and 6.0 in stomach in experimental group were (73.36 ± 21.08)% and (53.22 ± 23.76)%, in control group were (13.28 ± 10.55)% and (3.92 ± 2.17)%, there were significant differences (P < 0.01). Conclusions The strength of acid suppresion of lansoprazole injection is worthy of approving, and it can work at full capacity in treatment of patients with peptic ulcer complicated with upper gastrointestinal hemorrhage if lansoprazole is given every 12 h. Key words: Proton pump inhibitors; Lansoprazole injection; Acid-related disorders