Abstract
This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40–60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20. Subjects were administered 1 × 108 CFU/day MENOLACTO or placebo, with the primary endpoint being total KMI score, and the effect of secondary endpoints on alleviating menopausal symptoms according to individual categories of the modified KMI, as well as a quality of life questionnaire (MENQOL questionnaire). After 12 weeks, total KMI scores decreased significantly, demonstrating improved menopausal symptoms relative to placebo along with improved modified KMI scores. Additionally, quality of life, according to the MENQOL questionnaire, significantly improved in all four symptoms—physical, psychosocial, vasomotor, and sexual symptoms. Moreover, we observed no significant difference between the two groups or significant changes in blood follicle-stimulating hormone and estradiol levels or endometrial thickness. These results demonstrated that MENOLACTO alleviated menopausal symptoms without notable side effects and improved quality of life, suggesting its efficacy as an alternative supplement to alleviate menopausal symptoms in women ineligible for hormonal therapy.
Highlights
Menopause is a natural physiological status in women caused by loss of ovarian follicular-reproduction function through aging and diagnosed following the absence of menstrual periods for 12 consecutive months
We recently identified changes in intestinal microbes between a control group and a menopause animal model, with notable reductions observed in Lactobacillus acidophilus YT1 (MENOLACTO®) [34,35]
This study was a 12-week, multi-center, randomized, double-blinded, placebo-controlled human study that evaluated the effect of live L. acidophilus YT1 (1 × 108 colony-forming units (CFU)/day) on improving menopausal symptoms according to the Kupperman index (KMI)
Summary
Menopause is a natural physiological status in women caused by loss of ovarian follicular-reproduction function through aging and diagnosed following the absence of menstrual periods for 12 consecutive months. Menopause occurs in most women between the ages of 45 and 55, timing and symptoms can vary depending on the individual. Menopausal symptoms are increasingly recognized as having significant health implications through decreases in estrogen levels and lower estrogen exposure [1,2]. Given the increases in life expectancy, many women typically spend more than one-third of their entire life in a menopausal state [5]. Because menopause and its symptoms represent a known physiological phenomenon, there is a lack of awareness regarding symptom prevention and treatment
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