Abstract
Immunoglobulin determinations (IgA, IgG, and IgM) were performed in paired bloods from mother and umbilical cord at delivery in three groups of women: (1) those delivered vaginally; (2) those delivered by cesarean section following varying periods of labor; and (3) those delivered by elective cesarean section. In neither maternal nor cord sera were there significant differences in IgA and IgM concentrations among these groups. Neither were there significant differences in the IgG concentrations in the maternal sera in the three groups. However, in cord sera there was a statistically significant difference for IgG concentration in neonates delivered vaginally but none in the two groups delivered by cesarean section. A reasonable interpretation of this difference suggests that IgG is actively transported across the placenta only in the normal delivery group and that the actual time of labor is not a critical factor for the placental transfer of IgG.
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