Abstract
It has been proposed that in mares fertility could be affected by uterine blood flow [Blaich U,et.al,. Pferdeheilkunde 1999;15:547-50].An adequate blood supply is essential for hormonal signalling, uterine contractility, placentation and feto-endometrial interactions (Le Blanc MM, Causey RC. Reprod Domest Anim 2009;44:11-22.The objective of this study was to investigate the effects of the exogenous application of the vasodilator nitric oxide donor isosorbide dinitrate (ISDN) on uterine and ovarianperfusion in cycling mares and early pregnant mares by using transrectal Doppler ultrasonography. Six Trotter mares, aged 7 to 14 years were examined daily during three oestrous cycles. Four of these mares were additionally examined during early pregnancy. Mares were treated with placebo (lactose 60 mg), a low dose of ISDN (30 mg) and a high dose of ISDN (60 mg) orally (one treatment per cycle, in random order) every 12 h from Day 1 to 11 of the cycle (Day 0 1⁄4 day of ovulation following prostaglandin-induced luteolysis). Four of these mares were additionally treated with a placebo (lactose 60mg) or ISDN (60mg) orally every 12 h fromDay 1 to 11 after insemination. The uterine and ovarian blood supplies were studied by Doppler ultrasonography of both uterine arteries and both ovarian arteries once a day
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
