Abstract
AbstractIsonicotinic acid hydrazide (INH) was administered as a 0.1% solution in the drinking water for the life span of adult AKR inbred mice. The treatment resulted in no significant inhibitory effect on the development of malignant lymphomas which are characteristic of these animals, nor did it induce other tumors.Similar administration of INH as 0.05 and 0.15% solutions to adult randomly bred Swiss mice enhanced the formation of pulmonary adenomas, while it had no apparent inhibitory influence on the progression of other types of tumors.Single doses of 500, 400, 300, 250, 200 and 100 μg of INH were injected subcutane‐ously on the day of birth to Swiss mice, without significant tumorigenic effect.The problem of tumor induction versus inhibition is discussed.
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