Abstract
Background: Only a few published studies have directly demonstrated the effects of local soy isoflavone on the post-menopausal vaginal maturation index. This study focused on the effect of 24 weeks of local soy isoflavone (67,5 mg) consumption to improve the post-menopausal vaginal maturation index.
 Material and Methods: 50 post-menopausal women were randomly assigned to a double-blind clinical trial to receive cowpea (Vigna unguiculata) powder treatment (n=25) and placebo (n=23). Vaginal cytology (maturation index, maturation value) was evaluated at pre and post-treatment in Anatomy Pathology Laboratories. Collected data were analyzed by using the analysis of covariant (ANOVA) method.
 Result: There is no difference in maturation vaginal index between the treatment and the placebo group. The treatment was not significantly improved the vaginal maturation index (p<0,05). The concomitant variable, age, post-menopausal interval, BMI, marital status, and initial cell condition have no significant effect on the maturation vagina index.
 Conclusion: Cowpea powder supplement with 67,5 mg isoflavone cannot improve the vaginal maturation index on post-menopausal patients.
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