Abstract
The effect of prior i.v. injection of iron-dextran on biodistribution of [ 99 m Tc]Sn-pyrophosphate in rats was studied. Rats primed with 100 μmol of Fe/Kg as iron-dextran had significantly higher 99 m Tc activities in plasma and kidneys as compared to controls given saline or dextran, or to rats receiving lower concentrations of iron-dextran. When a mixture of irond-extran and [ 99 m Te]pyrophosphate was applied to a Sephadex G25 column, a complex of iron-dextran [ 99 m Tc]pyrophosphate could be identified, which, on injection into rats, concentrated in plasma and kidneys with little bone-seeking property. Scintigraphy of the rats showed excessive blood pool labelling and an increased renal uptake similar to that observed in humans who have received iron-dextran prior to skeletal scintigraphy with [ 99 m Tc]pyrophosphate. These changes were produced only by a combination of iron-dextran and [ 99 m Tc]pyrophosphate suggesting direct complexing of these compounds.
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