The effect of Ipomoea reptans, Poir self-nanoemulsifying drug delivery systems (SNEDDS) on the development of zebrafish (Danio rerio) embryos

Abstract

This study aimed to determine the effect of Self-Nanoemulsifying Drug Delivery Systems SNEDDS extract of kangkong (Ipomoea reptans, Poir) on the development of zebrafish embryos. Toxicity studies on zebrafish embryos each used 6 groups consisting of 3 control groups and 3 treatment groups. The control group consisted of solvent control, normal control, and positive control. The treatment group consisted of a concentration of 100 µg/mL, 50 µg/mL, and 25 µg/mL. Observations were carried out every 24 hours for 96 hours (4 days). Parameters of embryo mortality observed were coagulation, the formation of somites, detachment of tailbud from the yolk, and heart rate. From the experiment, it was concluded that the SNEDDS of kangkong (Ipomoea reptans, Poir) leaf extract did not affect the development of zebrafish embryos.